Chlorpyrifos Acts as a Positive Modulator and an Agonist of <i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity

Chlorpyrifos Acts as a Positive Modulator and an Agonist of <i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity

Chlorpyrifos (CPF) is a broad-spectrum organophosphate insecticide. Long-term exposure to low levels of CPF is associated with neurodevelopmental and neurodegenerative disorders. The mechanisms leading to these effects are still not fully understood. Normal NMDA receptor (NMDAR) function is essentia...

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Bibliographic Details
Main Authors: Mahmoud Awad Sherif, Wayne G. Carter, Ian R. Mellor
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Journal of Xenobiotics
Subjects:
chlorpyrifos
organophosphate
neurotoxicity
NMDA receptors
stem cells
<i>Xenopus</i> oocytes
Online Access:https://www.mdpi.com/2039-4713/15/1/12
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