RB1 expression and HR proficiency define a poor prognosis subtype of high grade serous ovarian cancer

RB1 expression and HR proficiency define a poor prognosis subtype of high grade serous ovarian cancer

Abstract High-grade serous ovarian carcinoma (HGSOC) is a molecularly heterogeneous and lethal malignancy, with late-stage diagnosis contributing to high risk of recurrence and poor clinical outcomes. Although homologous recombination (HR) deficiency and retinoblastoma gene (RB1) expression have bee...

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Main Authors: Kyle C. Strickland, Zachary D. Wallen, Heidi C. Ko, Michelle F. Green, Alicia Dillard, Sarabjot Pabla, Stephanie Hastings, Alison Roos, Taylor J. Jensen, Marcia Eisenberg, Brian J. Caveney, Shakti Ramkissoon, Eric A. Severson, Rebecca A. Previs
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
High grade serous ovarian carcinoma
Papillary serous adenocarcinoma
Ovarian cancer
Gynecologic oncology
Homologous recombination deficiency
RB1
Online Access:https://doi.org/10.1038/s41598-025-15156-9
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https://doi.org/10.1038/s41598-025-15156-9

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