S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

PurposeS-palmitic acid-9-hydroxy stearic acid (SP), a newly characterized endogenous lipid with multifaceted biological activities, is poised to shed light on its potential in diabetes-related cognitive disorder (DRCD). This study aims to uncover the effects of SP on DRCD and the underlying mechanis...

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Main Authors: Xin-Ru Wang, Shan-Shan Huang, Meng Wang, Jin-Hong Lin, Jian-Tao Wang, Jiao-Qi Ren, Cheng-Feng He, Wen-Jiao Xue, Yin Wang, Xue-Chun Wang, Yan-Li Zhang, Ji-Chang Xiao, Jing-Chun Guo, Hou-Guang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
S-9-PAHSA
diabetes-associated cognitive disorder
oxidative stress
mitochondrial dysfunction
CAIII
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1617543/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1617543/full

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