Major nuclear locales define nuclear genome organization and function beyond A and B compartments

Major nuclear locales define nuclear genome organization and function beyond A and B compartments

Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here, we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nu...

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Bibliographic Details
Main Authors: Omid Gholamalamdari, Tom van Schaik, Yuchuan Wang, Pradeep Kumar, Liguo Zhang, Yang Zhang, Gabriela A Hernandez Gonzalez, Athanasios E Vouzas, Peiyao A Zhao, David M Gilbert, Jian Ma, Bas van Steensel, Andrew S Belmont
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
genome organization
nuclear structure
nuclear lamina
nuclear speckles
nucleoli
Online Access:https://elifesciences.org/articles/99116
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https://elifesciences.org/articles/99116

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