The landscape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential

The landscape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential

Abstract Background Helicobacter pylori (H. pylori) infection is a significant risk factor for gastric cancer (GC) development. A growing body of evidence suggests a causal link between infection with H. pylori and increased DNA breakage in the host cells. While several mechanisms have been proposed...

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Main Authors: Hadas Sibony-Benyamini, Rose Jbara, Tania Shubash Napso, Layan Abu-Rahmoun, Daniel Vizenblit, Michal Easton-Mor, Shira Perez, Alexander Brandis, Tamar Leshem, Avi Peretz, Yaakov Maman
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Genome Medicine
Subjects:
Gastric cancer
Helicobacter pylori
Genome-instability
Replication stress
dNTP depletion
RRM2
Online Access:https://doi.org/10.1186/s13073-025-01439-3
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https://doi.org/10.1186/s13073-025-01439-3

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