Two-stage CD8+ CAR T-cell differentiation in patients with large B-cell lymphoma

Two-stage CD8+ CAR T-cell differentiation in patients with large B-cell lymphoma

Abstract Advancements in chimeric antigen receptor (CAR) T-cell therapy for treating diffuse large B-cell lymphoma (DLBCL) have been limited by an incomplete understanding of CAR T-cell differentiation in patients. Here, we show via single-cell, multi-modal, and longitudinal analyses, that CD8+ CAR...

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Main Authors: Guoshuai Cao, Yifei Hu, Tony Pan, Erting Tang, Nicholas Asby, Thomas Althaus, Jun Wan, Peter A. Riedell, Michael R. Bishop, Justin P. Kline, Jun Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59298-w
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https://doi.org/10.1038/s41467-025-59298-w

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