Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome

Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome

Abstract Background Although studies have evaluated the presence of cell-free DNA and neutrophil extracellular traps (NETs) in acute respiratory distress syndrome (ARDS), the kinetics of NET formation during the early ICU admission and whether plasma NET markers correlate with clinical outcomes in p...

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Main Authors: Joni A. Aoki, Frederik Denorme, Mark J. Cody, David P. Perry, John L. Rustad, Samuel M. Brown, Stephanie A. Goldstein, Elizabeth A. Middleton, Christian C. Yost, Estelle S. Harris, for the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Inflammation
Subjects:
Acute respiratory distress syndrome (ARDS)
Neutrophil extracellular traps (NETs)
Surrogate markers
Cell-free DNA fluorescence assay
Plasma myeloperoxidase (MPO)-DNA complex ELISA
Clinical outcomes
Online Access:https://doi.org/10.1186/s12950-025-00448-8
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https://doi.org/10.1186/s12950-025-00448-8

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