Improving treatment for Parkinson's disease: Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier

Improving treatment for Parkinson's disease: Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier

Parkinson's disease (PD) poses a significant therapeutic challenge, mainly due to the limited ability of drugs to cross the blood-brain barrier (BBB) without undergoing metabolic transformations. Levodopa, a key component of dopamine replacement therapy, effectively enhances dopaminergic activi...

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Bibliographic Details
Main Authors: Kaili Liang, Li Yang, Jiawei Kang, Bo Liu, Ding Zhang, Liyan Wang, Wei Wang, Qing Wang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Levodopa
Oxidative stress
Blood-brain barrier
Photothermal effect
Phagocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087624000801
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