New Derivatives of Caracasine Acid with Anti-Leukemic Activity and Limited Effectiveness in Spheroid Cultures

New Derivatives of Caracasine Acid with Anti-Leukemic Activity and Limited Effectiveness in Spheroid Cultures

<b>Background:</b> The natural compounds caracasine acid (<b>1</b>) and its methyl ester, caracasine (<b>2</b>), isolated from the flowers of <i>Croton micans</i>, are effective against several tumor cell lines. Five semi-synthetic derivatives (<b&g...

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Bibliographic Details
Main Authors: Alírica Isabel Suárez, Katiuska Chávez, Jenny Valentina Garmendia, Claudia Valentina De Sanctis, Soňa Gurská, Petr Džubák, Marian Hajduch, Juan Bautista De Sanctis
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
caracasine acid derivatives
cytotoxicity
leukemia
spheroids
Online Access:https://www.mdpi.com/1424-8247/18/7/1043
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