Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction

Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction

Abstract Background SPP1 + macrophages are among the major phagocytic cells, yet promoting tumor immune evasion and predicting unfavorable prognosis, in various cancer types. Meanwhile, the predictive value of the abundance of SPP1 + macrophages in patients receiving immunotherapy remains debatable,...

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Main Authors: Kun Chen, Yida Li, Jianjiao Ni, Xi Yang, Yue Zhou, Yechun Pang, Ruiting Ye, Hongru Chen, Silai Yu, Peng Wang, Zhengfei Zhu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Experimental Hematology & Oncology
Subjects:
Esophageal squamous cell carcinoma
SPP1 + macrophages
SIRPα
Tumor microenvironment
Immunotherapy
Online Access:https://doi.org/10.1186/s40164-024-00587-3
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https://doi.org/10.1186/s40164-024-00587-3

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