Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer

Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer

Abstract HER2 is a membrane receptor tyrosine kinase overexpressed in 18–20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2+) cancer cells with a chemotherapeutic agent, emtansine. T-DM1 has low efficacy in HER2+ gastric cancer....

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Bibliographic Details
Main Authors: Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A. Davis, Patrícia M. R. Pereira
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
HER2
T-DM1
Neratinib
Statin
ImmunoPET
Online Access:https://doi.org/10.1038/s41598-025-01947-7
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https://doi.org/10.1038/s41598-025-01947-7

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