Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca2 + ]i stability

Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca2 + ]i stability

Fine particulate matter (PM2.5) is toxic to reproduction and can cause a range of reproductive disorders. However, the mechanisms underlying female reproductive impairment due to PM2.5 exposure are unclear. In this study, we aimed to investigate the effects of PM2.5 on rat ovaries and the underlying...

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Bibliographic Details
Main Authors: Zhenhua Ma, Xiaohui Du, Cuizhu Zhao, Yize Sun, Yunna Jia, Xiaojun Liang, Xiuzhen Yu, Yunhang Gao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
Premature ovarian failure
Regulator of G protein signaling 2
Ovarian granulosa cells
Intracellular Ca2+
Gq/11
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325008826
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http://www.sciencedirect.com/science/article/pii/S0147651325008826

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