Bifidobacterium pseudolongum‐Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP‐PKG‐mTORC1 Pathway

Bifidobacterium pseudolongum‐Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP‐PKG‐mTORC1 Pathway

Abstract Carvacrol and thymol (CAT) have been widely recognized for their antimicrobial and anti‐inflammatory properties, yet their specific effects on colitis and the mechanisms involved remain insufficiently understood. This study establishes a causative link between CAT administration and colitis...

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Main Authors: Ke Zhang, Yangbin Xu, Yining Zheng, Ting Zhang, Yujiang Wu, Yiting Yan, Yu Lei, Xi Cao, Xiaolong Wang, Frances Yan, Zhaomin Lei, Daniel Brugger, Yulin Chen, Lu Deng, Yuxin Yang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
12‐ketodeoxycholic acid
bile acid
gut microbiota
inflammatory bowel disease
mTOR
Online Access:https://doi.org/10.1002/advs.202406917
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https://doi.org/10.1002/advs.202406917

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