Generation of a transgene-free Induced pluripotent stem (iPS) cell line (JNCHi002-A) from a female heterozygous carrier of the low density lipoprotein receptor (LDLR) gene mutation (c.387delC)

Generation of a transgene-free Induced pluripotent stem (iPS) cell line (JNCHi002-A) from a female heterozygous carrier of the low density lipoprotein receptor (LDLR) gene mutation (c.387delC)

The low density lipoprotein receptor （LDLR) gene (OMIM#606945)encodes a protein of 860 amino acids. The encoded protein typically anchors itself to the cell membrane, where it facilitates the binding and internalization of low-density lipoprotein/cholesterol into the cell. Once inside, lysosomes lib...

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Main Authors: Rujin Tian, Yixiao Li, Hongmei Xin, Yue Jiang, Haozheng Zhang, Lin Zhong, Zhongtao Gai, Qianqian Deng, Chunhui Wang, Kaihui Zhang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506125000066
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