Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria—A Long‐Term CMR Study

Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria—A Long‐Term CMR Study

ABSTRACT Background Despite a phenylalanine (Phe) restrictive diet, most adult patients with ‘classical’ phenylketonuria (PKU) maintain life‐long Phe concentrations above the normal range and receive tyrosine (Tyr) and protein‐enriched diets to maintain acceptable concentrations and ensure normal de...

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Bibliographic Details
Main Authors: Radu Tanacli, Patrick Doeblin, Alessandro Faragli, Jan‐Hendrik Hassel, Christian Stehning, Ursula Plöckinger, Athanasia Ziagaki, Sebastian Kelle
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
cardiac magnetic resonance imaging
cardiac remodelling
contractile impairment
metabolic disease
phenylketonuria
Online Access:https://doi.org/10.1002/jcsm.13667
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https://doi.org/10.1002/jcsm.13667

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