Gold Nanoparticles as a Platform for Delivery of Immunogenic Peptides to THP-1 Derived Macrophages: Insights into Nanotoxicity

Gold Nanoparticles as a Platform for Delivery of Immunogenic Peptides to THP-1 Derived Macrophages: Insights into Nanotoxicity

Background: Peptide-based nanovaccines have emerged as a promising strategy for combating infectious diseases, as they overcome the low immunogenicity that is inherent to short epitope-containing synthetic peptides. Gold nanoparticles (AuNPs) present several advantages as peptide nanocarriers, but a...

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Bibliographic Details
Main Authors: Eduardo Zúñiga, Braulio Contreras-Trigo, Jorge Buchert, Fabián Sáez-Ahumada, Leonardo Hernández, Víctor Fica-León, Estefania Nova-Lamperti, Bostjan Kobe, Fanny Guzmán, Víctor Diaz-García, Enrique Guzmán-Gutiérrez, Patricio Oyarzún
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
peptide-based nanovaccination
epitope-based vaccination
gold nanoparticle
T-cell epitope
nanotoxicity
cathepsin B activity
Online Access:https://www.mdpi.com/2076-393X/13/2/119
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