Impact of ATF6 deletion on the embryonic brain development

Impact of ATF6 deletion on the embryonic brain development

Summary: Although the unfolded protein response (UPR) is activated during brain development, its roles remain unclear. Here, we report that deletion of activating transcription factor 6 (ATF6), consisting of ATF6α and ATF6β, in the developing brain caused microcephaly and neonatal death in mice. Ana...

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Main Authors: Loc Dinh Nguyen, Ly Huong Nguyen, Dat Xuan Dao, Tsuyoshi Hattori, Mika Takarada-Iemata, Hiroshi Ishii, Takashi Tamatani, Hiroshi Kawasaki, Yohei Shinmyo, Kenta Onoue, Shigenobu Yonemura, Jun Zhang, Masato Miyake, Seiichi Oyadomari, Kazutoshi Mori, Osamu Hori
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Neuroscience
Cell biology
Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008302
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http://www.sciencedirect.com/science/article/pii/S2589004225008302

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