Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model

Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model

Abstract Background The autosomal recessive deafness 9 (DFNB9) is caused by mutations in the otoferlin gene that accounts for 2–8% of all inherited deafness cases. In a previous study, we demonstrated that Adeno-associated virus (AAV) gene therapy restored hearing in a preclinical mouse model of pro...

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Main Authors: Najate Benamer, Hélène Le Ribeuz, Chloé Felgerolle, Charlotte Calvet, Olivier Postal, Baptiste Plion, Mauricio Saenz-Roldan, Marie Giorgi, Marie-José Lecomte, Yann Nguyen, Christine Petit, Nicolas Michalski, Boris Gourévitch, Omar Akil, Saaid Safieddine
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00926-3
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https://doi.org/10.1038/s43856-025-00926-3

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