Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting

Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting

Abstract Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen and progesterone receptors, and lack of human epidermal growth factor receptor 2 (HER2) expression. Traditional Chinese medicine (TCM) has demonstrated promising efficacy in treating TNBC. This study explored t...

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Bibliographic Details
Main Authors: Ming Liu, Li Zheng, Yang Zhang, Jinhui Tian
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Pachymic acid
Triple-negative breast cancer
TOP2A
Network pharmacology
Vitro experiments
Online Access:https://doi.org/10.1038/s41598-025-87286-z
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https://doi.org/10.1038/s41598-025-87286-z

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