Ovarian steroids modulate mRNA expression of ECM associated genes and collagen deposition induced by TGF β1 in equine endometrium in vitro

Ovarian steroids modulate mRNA expression of ECM associated genes and collagen deposition induced by TGF β1 in equine endometrium in vitro

Abstract Equine endometrosis is a major cause of infertility in mares and is characterized by degenerative, functional and fibrotic changes in the endometrium with increased collagen (COL) deposition. Transforming growth factor (TGF)-β1 is one of the major pro-fibrotic factors involved in the excess...

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Main Authors: Ana Amaral, Agnieszka Sadowska, Marta Cerveira-Pinto, Pawel Kordowitzki, Dariusz Skarzynski, Graça Ferreira-Dias, Anna Szóstek-Mioduchowska
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Endometrosis
Mare
Transforming growth factor-β1
17β-estradiol
Progesterone
Online Access:https://doi.org/10.1038/s41598-024-84250-1
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https://doi.org/10.1038/s41598-024-84250-1

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