Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab

Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab

Abstract Background Kappa free light chains (KFLC), a byproduct of immunoglobulin (Ig) synthesis by B-lineage cells, can serve as an indicator for inflammatory activity. In multiple sclerosis (MS), especially the intrathecal KFLC production has gained increasing importance as a biomarker for central...

Full description

Saved in:
Bibliographic Details
Main Authors: Franz Felix Konen, Gudrun Mechthild Körner, Martin W. Hümmert, Philipp Sebastian Gehring, Philipp Schwenkenbecher, Konstantin Fritz Jendretzky, Sandra Nay, Nora Möhn, Lea Grote-Levi, Kurt-Wolfram Sühs, Elke Voß, Refik Pul, Torsten Witte, Thomas Skripuletz, Stefan Gingele
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Neurological Research and Practice
Subjects:
Multiple sclerosis
Ocrelizumab
Kappa free light chains
Serum
Biomarker
Online Access:https://doi.org/10.1186/s42466-025-00419-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s42466-025-00419-7

Similar Items