Stable preparation of in vivo transplantable periodontal ligament-derived mesenchymal stem cell sheets in thermoresponsive culture dishes with tunable cell detachability

Stable preparation of in vivo transplantable periodontal ligament-derived mesenchymal stem cell sheets in thermoresponsive culture dishes with tunable cell detachability

Tissue engineering plays a pivotal role in the advancement of regenerative medicine. Thermoresponsive culture dishes, coated with specialized polymers that control cell adhesion through temperature fluctuations, enable the processing of cells into sheets for medical applications while maintaining th...

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Main Authors: Kazuki Morita, Masamichi Nakayama, Jiacheng Wang, Satoru Onizuka, Masahiro Hatasa, Yujin Ohsugi, Yosuke Tsuchiya, Hiromi Niimi, Anhao Liu, Hideaki Sakai, Teruo Okano, Takanori Iwata
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Regenerative Therapy
Subjects:
Cell sheet
Thermoresponsive culture dish
Polymer coating method
Periodontitis
Periodontal ligament derived mesenchymal stem cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320425000045
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