Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3

Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3

IntroductionRespiratory syncytial virus (RSV) causes significant lower-respiratory-tract disease in high-risk groups. A phase IIb trial showed that a combination vaccine of Ad26-vectored prefusion RSV F (Ad26.preF) plus soluble prefusion F protein (SpreF) was 80 % protective, yet the longevity and f...

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Main Authors: Xin Tong, Ross Blanc, Deniz Cizmeci, Hadar Malca, Jaewon Kang, Christy Comeaux, Benoit Callendret, Arangassery Rosemary Bastian, Mehak Zahoor Khan, Galit Alter, Daniel Lingwood, Ryan P. McNamara
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
prefusion glycoprotein
RSV
vaccine
adenovirus vector
antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609779/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609779/full

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