Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia

Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia

Acute myeloid leukemia (AML) patients with high PRDM16 expression frequently experience induction failure and have a poor prognosis. However, the molecular mechanisms underlying these clinical features remain elusive. We found that murine AML cells transformed by MLL::AF9 fusion and oncogenic short...

Full description

Saved in:
Bibliographic Details
Main Authors: Junji Ikeda, Hiroyoshi Kunimoto, Yusuke Saito, Shin-Ichi Tsujimoto, Masanobu Takeuchi, Ayaka Miura, Takayuki Kurosawa, Koichi Murakami, Ikuma Kato, Megumi Funakoshi-Tago, Akihiko Yokoyama, Norio Shiba, Souichi Adachi, Daisuke Tomizawa, Tomohiko Tamura, Shuichi Ito, Hideaki Nakajima
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-06-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12105
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://haematologica.org/article/view/12105

Similar Items