Siramesine induced cell death of glioblastoma through inactivating the STAT3-MGMT signaling pathway

Siramesine induced cell death of glioblastoma through inactivating the STAT3-MGMT signaling pathway

Abstract Background Glioblastoma (GBM), the most prevalent invasive primary brain tumor in adults, is characterized by high mortality, frequent recurrence, and short survival time. The effectiveness of temozolomide (TMZ) in treating GBM is compromised by chemoresistance. Elevated levels of O6-methyl...

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Bibliographic Details
Main Authors: Xiaohang Cui, Anhui Yao, Jinquan Lv, Chi Zhang, Yue Chen, Tingjie Mei, Hengzeng Li, Yahui Wu, Liyun Jia
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Glioblastoma
Temozolomide
Siramesine
Drug resistance
STAT3
MGMT
Online Access:https://doi.org/10.1186/s12967-025-06693-y
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https://doi.org/10.1186/s12967-025-06693-y

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