Engineering Pichia pastoris for the efficient production of the high-value steroid intermediate 15α-OH-D-ethylgonendione
Abstract 15α-OH-D-ethylgonendione (15α-OH-DE) is a key intermediate for the synthesis of steroid drug gestodene, a major component of a new generation of powerful contraceptives. Synthetic access to 15α-OH-DE by chemical means is limited by low titers and generation of toxic byproducts. To develop a...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Microbial Cell Factories |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12934-025-02796-9 |
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