Engineering Pichia pastoris for the efficient production of the high-value steroid intermediate 15α-OH-D-ethylgonendione

Engineering Pichia pastoris for the efficient production of the high-value steroid intermediate 15α-OH-D-ethylgonendione

Abstract 15α-OH-D-ethylgonendione (15α-OH-DE) is a key intermediate for the synthesis of steroid drug gestodene, a major component of a new generation of powerful contraceptives. Synthetic access to 15α-OH-DE by chemical means is limited by low titers and generation of toxic byproducts. To develop a...

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Bibliographic Details
Main Authors: Yu-Long Zeng, Yang-Yang Li, Bei-Feng-Chu Zheng, Dong-Qi Xie, Sheng-Qiang Tong, Yuan Yuan, Ya-Jun Wang, Bin Xue, Xiao-Guang Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Microbial Cell Factories
Subjects:
Steroid 15α-hydroxylase
D-ethylgonendione
Pichia pastoris
Glucose-6-phosphate dehydrogenase
Fed-batch fermentation
Intermediate
Online Access:https://doi.org/10.1186/s12934-025-02796-9
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https://doi.org/10.1186/s12934-025-02796-9

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