Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model

Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model

Background Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 macrophage polarization remains elusive.Results The novel circ...

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Main Authors: Yang Liu, Chen Chen, Jinbo Liu, Zhenqiang Sun, Bo Shao, Yanxin Xu, Pengyuan Dang, Shengyun Hu, Haifeng Sun, Chaoguan Wang, Junhong Hu
Format: Article
Language:English
Published: BMJ Publishing Group 2024-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/5/e008491.full
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