Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study)

Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study)

Chagas disease (CD) can alter gut microbiota composition, although its functional impact is poorly defined. We conducted whole-genome metagenomic sequencing of stool samples from 55 adults with chronic CD (23 treated with benznidazole) and 17 non-infected controls. Functional pathways were annotated...

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Bibliographic Details
Main Authors: José A. Pérez-Molina, Elena Moreno, Clara Crespillo-Andújar, Sandra Chamorro-Tojeiro, Marta Arsuaga, Leticia Olavarrieta, Oihane Martín, Begoña Monge-Maillo, Francesca Norman, Val F. Lanza, Sergio Serrano-Villar
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Travel Medicine and Infectious Disease
Subjects:
Chagas disease
Microbiota
Migrants
Metabolic pathways
Benznidazole
Surrogate marker
Online Access:http://www.sciencedirect.com/science/article/pii/S1477893925000870
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