Synthesis of novel N-substituted β-amino acid derivatives bearing 2-hydroxyphenyl moieties as promising antimicrobial candidates targeting multidrug-resistant Gram-positive pathogens.

Synthesis of novel N-substituted β-amino acid derivatives bearing 2-hydroxyphenyl moieties as promising antimicrobial candidates targeting multidrug-resistant Gram-positive pathogens.

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The increasing prevalence of antimicrobial resistance among ESKAPE group pathogens presents a significant challenge in the healthcare sector, contributing to higher morbidity and mortality rates globally. Thus, it is essential to develop novel antimicrobial agents effective against drug-resistant pa...

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Main Authors: Povilas Kavaliauskas, Birutė Grybaitė, Birute Sapijanskaite-Banevič, Rūta Petraitienė, Ramunė Grigalevičiūtė, Andrew Garcia, Ethan Naing, Vytautas Mickevičius, Sergey Belyakov, Vidmantas Petraitis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0311715
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https://doi.org/10.1371/journal.pone.0311715

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