Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis

Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis

Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD) simulations to evaluate the potential of repurposing terfe...

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Main Authors: Pushpaveni C, Hemavathi S, Santosh Prasad Chaudhary Kurmi, Biswa Ranjan Patra, V Angelin Esther, Chandrajeet Kumar Yadav, Mahalakshmi Suresha Biradar, Shankar Thapa
Format: Article
Language:English
Published: SAGE Publishing 2025-08-01
Series:Bioinformatics and Biology Insights
Online Access:https://doi.org/10.1177/11779322251365019
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https://doi.org/10.1177/11779322251365019

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