Biomarker-driven drug repurposing for NAFLD-associated hepatocellular carcinoma using machine learning integrated ensemble feature selection

Biomarker-driven drug repurposing for NAFLD-associated hepatocellular carcinoma using machine learning integrated ensemble feature selection

The incidence of non-alcoholic fatty liver disease (NAFLD), encompassing the more severe non-alcoholic steatohepatitis (NASH), is rising alongside the surges in diabetes and obesity. Increasing evidence indicates that NASH is responsible for a significant share of idiopathic hepatocellular carcinoma...

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Bibliographic Details
Main Authors: Subhajit Ghosh, Sukhen Das Mandal, Subarna Thakur
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Bioinformatics
Subjects:
NAFLD
HCC
machine learning
ensemble feature selection
drug repurposing
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1522401/full
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https://www.frontiersin.org/articles/10.3389/fbinf.2025.1522401/full

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