Protein-bound uremic toxin clearance as biomarker of kidney tubular function in diabetic kidney disease

Protein-bound uremic toxin clearance as biomarker of kidney tubular function in diabetic kidney disease

Abstract Kidney tubular damage is an important prognostic determinant in diabetic kidney disease (DKD). A vital homeostatic function of the proximal tubule is active tubular secretion of waste products via organic anion transporters (OATs), including protein-bound uremic toxins (PBUTs) that accumula...

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Main Authors: Sabbir Ahmed, Rolf W. Sparidans, Robin W. M. Vernooij, Silvia M. Mihaila, Roel Broekhuizen, Roel Goldschmeding, Tri Q. Nguyen, Rosalinde Masereeuw, Karin G. F. Gerritsen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Diabetic kidney disease
Tubular function marker
Protein-bound uremic toxins
Indoxyl sulfate
Hippuric acid
Online Access:https://doi.org/10.1038/s41598-025-07248-3
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https://doi.org/10.1038/s41598-025-07248-3

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