Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1.

Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of Kaposi's sarcoma, encodes 25 mature viral miRNAs. MCP-1-induced protein-1 (MCPIP1), a critical regulator of immune homeostasis, has been shown to suppress miRNA biosynthesis via cleavage of precursor miRNAs through its...

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Bibliographic Details
Main Authors: Christine Happel, Dhivya Ramalingam, Joseph M Ziegelbauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-11-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2000998&type=printable
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