Development and validation of an innovative approach to estimating FVIII levels and designing personalised doses in the prophylactic treatment of haemophilia A: based on the principle of the two-compartment model

Development and validation of an innovative approach to estimating FVIII levels and designing personalised doses in the prophylactic treatment of haemophilia A: based on the principle of the two-compartment model

Objective To predict the level at a specified time and design personalised dosing, we proposed a method (Method 1) for estimating coagulation factor VIII (FVIII) pharmacokinetic (PK) parameters using 4 levels within 48 hours after administering a test dose.Design A retrospective study based on virtu...

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Main Authors: Xuemei Wu, Zipeng Wei, Jianxing Zhou, Baohua Xu, You Zheng, Qingxia Liu, Shuxia Zhang, Maobai Liu, Meijuan Huang, Fenge Yang
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/7/e097053.full
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https://bmjopen.bmj.com/content/15/7/e097053.full

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