Single-cell RNA sequencing reveals potential therapeutic targets in the tumor microenvironment of lung squamous cell carcinoma

Single-cell RNA sequencing reveals potential therapeutic targets in the tumor microenvironment of lung squamous cell carcinoma

Abstract Lung squamous cell carcinoma (LUSC), accounting for 30% of lung cancer cases, lacks adequate research due to limited understanding of its molecular abnormalities. Our study analyzed public LUSC datasets to explore the tumor microenvironment (TME) composition using scRNA-seq from two cohorts...

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Bibliographic Details
Main Authors: Junda Fan, Yu Chen, Yue Gong, Hongmei Sun, Rui Hou, Xiaoya Dou, Yanping Zhang, Cheng Huo
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Single-cell RNA sequencing
Lung cancer
Tumor microenvironment
Non-negative matrix factorization
Bioinformatics
Online Access:https://doi.org/10.1038/s41598-025-93916-3
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https://doi.org/10.1038/s41598-025-93916-3

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