Preclinical evaluation of [68Ga]Ga-AAZTA-FAPI-46: a novel PET tracer for targeting fibroblast activation protein (FAP)

Preclinical evaluation of [68Ga]Ga-AAZTA-FAPI-46: a novel PET tracer for targeting fibroblast activation protein (FAP)

Abstract Background The aim of this work was to demonstrate the suitability of AAZTA chelator conjugated to a FAPI-46-derived FAP inhibitor and labelled with gallium-68 as a potential PET tracer. Results Gallium-68 radiolabelling was achieved with high radiochemical yield at room temperature. The ne...

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Bibliographic Details
Main Authors: Rebecca Rizzo, Paolo Rainone, Rachele Stefania, Sara Belloli, Silvia Valtorta, Angela Coliva, Marco Maspero, Lidia Avalle, Martina Capozza, Rosa Maria Moresco, Calogero D’Alessandria, Enzo Terreno
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
AAZTA
FAP
PET
FAPI-46
GALLIUM-68
Online Access:https://doi.org/10.1186/s41181-025-00375-2
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https://doi.org/10.1186/s41181-025-00375-2

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