Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding

Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding

Abstract In pharmacology, it is crucial to understand the complex biological responses that drugs elicit in the human organism and how well they can be inferred from model organisms. We therefore identified a large set of drug‐induced transcriptional modules from genome‐wide microarray data of drug‐...

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Bibliographic Details
Main Authors: Murat Iskar, Georg Zeller, Peter Blattmann, Monica Campillos, Michael Kuhn, Katarzyna H Kaminska, Heiko Runz, Anne‐Claude Gavin, Rainer Pepperkok, Vera van Noort, Peer Bork
Format: Article
Language:English
Published: Springer Nature 2013-04-01
Series:Molecular Systems Biology
Subjects:
cell line models in drug discovery
drug‐induced transcriptional modules
drug repositioning
gene function prediction
transcriptome conservation across cell types and organisms
Online Access:https://doi.org/10.1038/msb.2013.20
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https://doi.org/10.1038/msb.2013.20

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