HER-2/neu Amplification Testing in Breast Cancer by Multiplex Ligation-Dependent Probe Amplification in Comparison with Immunohistochemistry and In Situ Hybridization

HER-2/neu Amplification Testing in Breast Cancer by Multiplex Ligation-Dependent Probe Amplification in Comparison with Immunohistochemistry and In Situ Hybridization

Background: Assessment of HER-2/neu status in invasive breast cancer is crucial to establish eligibility for trastuzumab and taxane based chemotherapy. Next to immunohistochemistry (IHC) to evaluate protein overexpression, a second line gene amplification test is required for cases with equivocal pr...

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Main Authors: Cathy B. Moelans, Roel A. de Weger, Marja T.M. van Blokland, Chantal Ezendam, Sabrina Elshof, Marcel G. J. Tilanus, Paul J. van Diest
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2009-0461
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http://dx.doi.org/10.3233/CLO-2009-0461

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