Quantifying and interpreting biologically meaningful spatial signatures within tumor microenvironments

Abstract The tumor microenvironment (TME) plays a crucial role in orchestrating tumor cell behavior and cancer progression. Recent advances in spatial profiling technologies have uncovered novel spatial signatures, including univariate distribution patterns, bivariate spatial relationships, and high...

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Bibliographic Details
Main Authors: Si-yu Jing, He-qi Wang, Ping Lin, Jiao Yuan, Zhi-xuan Tang, Hong Li
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00857-1
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