TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor predominantly expressed by microglia in the brain. Recent studies have established TREM2 as a central immune signaling hub in neurodegeneration, where it triggers immune responses upon sensing pathological...
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| Main Authors: | Lianshuai Zhang, Xianyuan Xiang, Yahui Li, Guojun Bu, Xiao-Fen Chen |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
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| Series: | Molecular Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13024-025-00834-z |
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