TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies

Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor predominantly expressed by microglia in the brain. Recent studies have established TREM2 as a central immune signaling hub in neurodegeneration, where it triggers immune responses upon sensing pathological...

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Bibliographic Details
Main Authors: Lianshuai Zhang, Xianyuan Xiang, Yahui Li, Guojun Bu, Xiao-Fen Chen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Neurodegeneration
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Online Access:https://doi.org/10.1186/s13024-025-00834-z
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