Increased eosinophils after oral corticosteroid treatment for asthma exacerbation correlated with longer ER stays and persisting thymic stromal lymphopoietin and increased Park2

Increased eosinophils after oral corticosteroid treatment for asthma exacerbation correlated with longer ER stays and persisting thymic stromal lymphopoietin and increased Park2

Abstract TSLP-regulated Park2 and mitophagy may be critical underlying driver of asthma exacerbations, as well as eosinophil responses to oral corticosteroids (OCS). However, detailed molecular knowledge of the molecular mechanisms involved is lacking. In a prospective cohort study at ED Siriraj Hos...

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Bibliographic Details
Main Authors: Kittipong Maneechotesuwan, Jirawat Assawabhumi, Jirabhorn Chankham, Kanda Kasetsinsombat, Khin Su Su Htwe, Ian M. Adcock
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Asthma exacerbation
Mitophagy
Mitochondrial DNA
Park2
Thymic stromal lymphopoietin
Online Access:https://doi.org/10.1038/s41598-025-07102-6
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https://doi.org/10.1038/s41598-025-07102-6

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