Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes

Objective: In autoimmune Type 1 Diabetes (T1D), aberrant immune activation promotes regulatory T cell (Treg) impairments thereby boosting progression of islet autoimmunity. Consequently, there is a progressive destruction of the insulin-producing beta cells in the pancreas. Controlling overshooting...

Full description

Saved in:
Bibliographic Details
Main Authors: Hannah Hipp, Camilla Tondello, Hanna Gmehling, Lena K. Scholz, Antigoni Stavridou, Maike Becker, Anne-Marie Bührer, Edith Hintermann, Sandra M. Dirschl, Till M. Johannsmann, Martin G. Scherm, Hella Kohlhof, Isabelle Serr, Urs Christen, Carolin Daniel
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Molecular Metabolism
Subjects:
Autoimmunity
Type 1 diabetes
Regulatory T cells
Immunomodulation
DHODH inhibition
Vidofludimus calcium
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001255
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2212877825001255

Similar Items