Pseudomonas aeruginosa elastase down-regulates host inflammatory responses by degrading cytokines and chemokines: a non-healing wound perspective

Pseudomonas aeruginosa elastase down-regulates host inflammatory responses by degrading cytokines and chemokines: a non-healing wound perspective

Non-healing venous leg ulcers are characterized by dysfunctional wound healing and frequently exhibit an absence of classical inflammatory signs, despite substantial bacterial loads of the Gram-negative pathogen Pseudomonas aeruginosa. To investigate this clinical observation, we used a porcine woun...

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Bibliographic Details
Main Authors: Mariena J. A. van der Plas, Manoj Puthia, Seow Theng Ong, Kajsa Arkelius, Ann-Charlotte Strömdahl, Marta Butrym, Magnus Rasmussen, Navin Kumar Verma, Artur Schmidtchen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Medicine
Subjects:
wound infection
porcine (pig) model
proteolytic acitivity
LasB elastase
monocytes
blood
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1585252/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1585252/full

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