Peripheral immune cell response to stimulation stratifies Parkinson’s disease progression from prodromal to clinical stages

Abstract The motor stage of Parkinson’s disease (PD) can be preceded for years by a prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder (RBD), hyposmia, and constipation. Here, we show that multiple stages of idiopathic PD, including the pre-motor prodromal stage, ca...

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Bibliographic Details
Main Authors: Julian R. Mark, Ann M. Titus, Hannah A. Staley, Stephan Alvarez, Savanna Mahn, Nikolaus R. McFarland, Rebecca L. Wallings, Malú Gámez Tansey
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08088-7
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