Identification of SnRNA U6 as an endogenous reference gene for normalization of MiRNA expression data in COVID-19 patients

Identification of SnRNA U6 as an endogenous reference gene for normalization of MiRNA expression data in COVID-19 patients

Abstract SARS-CoV-2, the virus responsible for COVID-19, exhibits structural differences compared to other coronaviruses that impact transmission dynamics and host response. Although vaccines have reduced severe hospitalizations and deaths, understanding the infection remains challenging, and findin...

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Main Authors: Íris Terezinha Santos de Santana Silva, Hllytchaikra Ferraz Fehlberg, Fabrício Barbosa Ferreira, Murillo Ferreira da Silva, Pérola Rodrigues dos Santos, Vinicius Moreira Porto, João Carlos Teixeira Dias, George Rego Albuquerque, Ana Paula Melo Mariano, Sandra Rocha Gadelha, Carla Martins Kaneto
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
Covid-19
miRNA
snRNAU6
Normalization
RT-qPCR
Online Access:https://doi.org/10.1038/s41598-025-04062-9
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https://doi.org/10.1038/s41598-025-04062-9

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