Pre-pandemic artificial MERS analog of polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among spike proteins of genus Betacoronavirus

Pre-pandemic artificial MERS analog of polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among spike proteins of genus Betacoronavirus

Abstract Objectives SARS-CoV-2 spike (S) glycoprotein furin cleavage site is a key determinant of SARS-CoV-2 virulence and COVID-19 pathogencity. Located at the S1/S2 junction, it is unique among sarbecoviruses but frequently found among betacoronaviruses. Recent evidence suggests that this site inc...

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Bibliographic Details
Main Author: Andreas Martin Lisewski
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Genomic Data
Subjects:
Genomics
Directed evolution
Artificial virus host
Betacoronavirus
Furin cleavage site
Nuclear localization signal
Online Access:https://doi.org/10.1186/s12863-024-01290-2
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https://doi.org/10.1186/s12863-024-01290-2

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