Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study
Background. Proteinuria has been related to all-cause mortality, showing regression or progression. However, few studies have focused on the relationship between proteinuria changes and all-cause mortality. The main purpose of this paper is to examine the associations between proteinuria changes and...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8368513 |
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| author | Yang Sun Anxin Wang Xiaoxue Liu Zhaoping Su Junjuan Li Yanxia Luo Shuohua Chen Jianli Wang Xia Li Zhan Zhao Huiping Zhu Shouling Wu Xiuhua Guo |
| author_facet | Yang Sun Anxin Wang Xiaoxue Liu Zhaoping Su Junjuan Li Yanxia Luo Shuohua Chen Jianli Wang Xia Li Zhan Zhao Huiping Zhu Shouling Wu Xiuhua Guo |
| author_sort | Yang Sun |
| collection | DOAJ |
| description | Background. Proteinuria has been related to all-cause mortality, showing regression or progression. However, few studies have focused on the relationship between proteinuria changes and all-cause mortality. The main purpose of this paper is to examine the associations between proteinuria changes and all-cause mortality in people with diabetes or prediabetes. Methods. Dipstick proteinuria at baseline and a 2-year follow-up were determined in the participants attending the Kailuan prospective cohort study. Participants were then divided into three categories: elevated proteinuria, stable proteinuria, and reduced proteinuria. Four Cox proportional hazard models were built to access the relations of proteinuria changes to all-cause mortality, adjusting for other confounding covariates. Results. A total of 17,878 participants were finally included in this study. There were 1193 deaths after a median follow-up of 6.69 years. After adjusting for major covariates and proteinuria at baseline, mortality risk was significantly associated with elevated proteinuria (hazard ratio (HR): 1.54, 95% confidence interval (CI): 1.33–1.79) and reduced proteinuria (HR: 0.70, 95% CI: 0.55–0.89), compared to those with stable proteinuria. Conclusion. Proteinuria changes were independently associated with mortality risk in either diabetic or prediabetic population. |
| format | Article |
| id | doaj-art-940da58e34ee4b1191b2d951d969cce4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-940da58e34ee4b1191b2d951d969cce42025-02-03T01:13:09ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/83685138368513Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort StudyYang Sun0Anxin Wang1Xiaoxue Liu2Zhaoping Su3Junjuan Li4Yanxia Luo5Shuohua Chen6Jianli Wang7Xia Li8Zhan Zhao9Huiping Zhu10Shouling Wu11Xiuhua Guo12Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Tangshan People’s Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Nephrology, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Rehabilitation, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Mathematics and Statistics, La Trobe University, Melbourne, AustraliaState Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaBackground. Proteinuria has been related to all-cause mortality, showing regression or progression. However, few studies have focused on the relationship between proteinuria changes and all-cause mortality. The main purpose of this paper is to examine the associations between proteinuria changes and all-cause mortality in people with diabetes or prediabetes. Methods. Dipstick proteinuria at baseline and a 2-year follow-up were determined in the participants attending the Kailuan prospective cohort study. Participants were then divided into three categories: elevated proteinuria, stable proteinuria, and reduced proteinuria. Four Cox proportional hazard models were built to access the relations of proteinuria changes to all-cause mortality, adjusting for other confounding covariates. Results. A total of 17,878 participants were finally included in this study. There were 1193 deaths after a median follow-up of 6.69 years. After adjusting for major covariates and proteinuria at baseline, mortality risk was significantly associated with elevated proteinuria (hazard ratio (HR): 1.54, 95% confidence interval (CI): 1.33–1.79) and reduced proteinuria (HR: 0.70, 95% CI: 0.55–0.89), compared to those with stable proteinuria. Conclusion. Proteinuria changes were independently associated with mortality risk in either diabetic or prediabetic population.http://dx.doi.org/10.1155/2017/8368513 |
| spellingShingle | Yang Sun Anxin Wang Xiaoxue Liu Zhaoping Su Junjuan Li Yanxia Luo Shuohua Chen Jianli Wang Xia Li Zhan Zhao Huiping Zhu Shouling Wu Xiuhua Guo Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study Journal of Diabetes Research |
| title | Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study |
| title_full | Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study |
| title_fullStr | Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study |
| title_full_unstemmed | Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study |
| title_short | Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study |
| title_sort | changes in proteinuria on the risk of all cause mortality in people with diabetes or prediabetes a prospective cohort study |
| url | http://dx.doi.org/10.1155/2017/8368513 |
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