Co-inhibition of Notch1 and ChK1 triggers genomic instability and melanoma cell death increasing the lifespan of mice bearing melanoma brain metastasis

Co-inhibition of Notch1 and ChK1 triggers genomic instability and melanoma cell death increasing the lifespan of mice bearing melanoma brain metastasis

Abstract Background Melanoma brain metastases (MBM) are a leading cause of death in patients with advanced disease. MBM treatment relay on targeted and immunotherapy and on stereotactic radiosurgery as gold standard. Life expectancy has improved significantly with these therapies however, targeted t...

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Main Authors: Varsha Thakur, Vijay S. Thakur, Dazhi Wang, Juliano Tiburcio de Freitas, Anna Bianchi, Luis Alberto Nivelo, Oliver Umland, Scott M. Welford, Barbara Bedogni
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Melanoma brain metastases
Anti-Notch1 antibody
ChK1 inhibition
Genomic instability
DNA damage
Online Access:https://doi.org/10.1186/s13046-025-03411-w
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https://doi.org/10.1186/s13046-025-03411-w

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